- Title
- Cost-Effectiveness Analysis of Renin-Angiotensin Aldosterone System Blockade in Progression of Chronic Kidney Disease.
- Creator
- Pattanaprateep, Oraluck; Ingsathit, Atiporn; McEvoy, Mark; Attia, John; Thakkinstian, Ammarin
- Relation
- Value in Health Regional Issues Vol. 15, p. 155-160
- Publisher Link
- http://dx.doi.org/10.1016/j.vhri.2017.12.011
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2018
- Description
- Objectives: To assess the cost effectiveness of renin-angiotensin aldosterone system (RAAS) blockade in the progression of chronic kidney disease using Thai clinical data in 2014. Methods: A Markov model for cost-effectiveness analysis was applied to estimate from a societal perspective the cost per quality-adjusted life-year (QALY) gained and the incremental cost-effectiveness ratio of RAAS versus non-RAAS used in preventing the progression of end-stage renal disease and death stratified by diabetic and nondiabetic patients. Input parameters related to clinical outcomes were obtained from a cohort study of treatment effectiveness, whereas costs were retrieved from the Ramathibodi Hospital electronic database in 2015 and the Health Intervention and Technology Assessment Program in Thailand. One-way analysis and probabilistic sensitivity analysis were performed to evaluate uncertainty surrounding model parameters. Results: From the model, using RAAS improved QALY from 2.41 to 3.16 years and from 2.37 to 3.20 years in diabetic and nondiabetic groups, respectively. The incremental cost-effectiveness ratios for these groups were 78,250 baht (US $2,353.39) and 66,674 baht (US $2,005.22), respectively. Conclusions: Using RAAS in patients with chronic kidney disease improved QALY in both diabetic and nondiabetic patients and proved to be cost-effective.
- Subject
- chronic kidney disease; cost effectiveness; renin-angiotensin-aldosterone system blockade; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1447398
- Identifier
- uon:43136
- Identifier
- ISSN:2212-1102
- Language
- eng
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